Chromatin regulation by BAF170 controls cerebral cortical size and thickness.

ABSTRACT: Increased cortical size is essential to the enhanced intellectual capacity of primates during mammalian evolution. The mechanisms that control cortical size are largely unknown. Here, we show that mammalian BAF170, a subunit of the chromatin remodeling complex mSWI/SNF, is an intrinsic factor that controls cortical size. We find that the conditional deletion of BAF170 promotes indirect neurogenesis by increasing the pool of intermediate progenitors (IPs) and results in an enlarged cortex, whereas cortex-specific BAF170 over-expression results an opposing phenotype. Mechanistically, BAF170 competes with BAF155 subunit in the BAF complex, affecting the euchromatin structure and thereby modulating the binding efficiency of Pax6/REST-corepressor complex to Pax6 target genes that regulate the g

ORGANISM(S): Mus musculus

SUBMITTER: Stephen Sansom 

PROVIDER: E-GEOD-45629 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress