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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human lung cancer patients with sqamous cell or adenocarcinoma at different stages of disease to identify gene signatures to predict prognosis

ABSTRACT: Gene signatures were derived to separate high risk patients from low risk ones. Experiment Overall Design: 130 samples from 129 patients

ORGANISM(S): Homo sapiens

SUBMITTER: Jack Yu

PROVIDER: E-GEOD-4573 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung.

Raponi Mitch M Zhang Yi Y Yu Jack J Chen Guoan G Lee Grace G Taylor Jeremy M G JM Macdonald James J Thomas Dafydd D Moskaluk Christopher C Wang Yixin Y Beer David G DG

Cancer research 20060801 15

Non-small-cell lung cancers (NSCLC) compose 80% of all lung carcinomas with squamous cell carcinomas (SCC) and adenocarcinoma representing the majority of these tumors. Although patients with early-stage NSCLC typically have a better outcome, 35% to 50% will relapse within 5 years after surgical treatment. We have profiled primary squamous cell lung carcinomas from 129 patients using Affymetrix U133A gene chips. Unsupervised analysis revealed two clusters of SCC that had no correlation with tumo ...[more]

PMID: 16885343

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