Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. II
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Terence Wu
PROVIDER: E-GEOD-4576 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas.
Hoek Keith K Rimm David L DL Williams Kenneth R KR Zhao Hongyu H Ariyan Stephan S Lin Aiping A Kluger Harriet M HM Berger Aaron J AJ Cheng Elaine E Trombetta E Sergio ES Wu Terence T Niinobe Michio M Yoshikawa Kazuaki K Hannigan Gregory E GE Halaban Ruth R
Cancer research 20040801 15
Affymetrix and spotted oligonucleotide microarrays were used to assess global differential gene expression comparing normal human melanocytes with six independent melanoma cell strains from advanced lesions. The data, validated at the protein level for selected genes, confirmed the overexpression in melanoma cells relative to normal melanocytes of several genes in the growth factor/receptor family that confer growth advantage and metastasis. In addition, novel pathways and patterns of associated ...[more]
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