Molecular insights into mild exercise-induced enhancement of spatial memory and neurogenesis: a DNA microarray approach

ABSTRACT: Many studies have reported on beneficial aspects of running to improve hippocampus-related spatial memory and promote neuroplastic changes like adult hippocampal neurogenesis (AHN). Such research has also revealed molecular factors associated with molecular signaling by BDNF and IGF-I leading to CREB activation. However, the optimum exercise intensity for genome-wide beneficial effects remains unclear. We thus investigate the whole spectrum of hippocampal molecular change by exercise using DNA microarray-based transcript profiling in two different intensity groups. Lactate threshold (LT), at which lactate starts to accumulate in the blood, defined the intensity: mild- (ME, LT). Rats were subjected to 6 weeks of training or sedentary (CONT) regimes. After 6 we

ORGANISM(S): Rattus norvegicus

SUBMITTER: Randeep Rakwal 

PROVIDER: E-GEOD-45813 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress