To identify gene markers which differentiate between AERD and ATA with a high discriminative power.

ABSTRACT: Aspirin-exacerbated respiratory disease (AERD) has association with severe asthma and aspirin can cause asthma to worsen, often in the form of a severe and sudden attack. The oral aspirin challenge (OAC) is the gold standard to confirm the diagnosis of AERD but it is time consuming and produces serious complications in some cases. Therefore more efficient and practical method is needed to predict AERD patients. The aim of the present study was to identify AERD-related gene expression in peripheral blood mononuclear cells (PBMCs) and examine the diagnostic potential of these candidate gene(s) for predicting AERD. To do this, RNAs from 24 subjects with AERD and 18 subjects with aspirin-tolerant asthma (ATA) were subjected to microarray analysis of ~34,560 genes. In total, 10 genes were selec

ORGANISM(S): Homo sapiens

SUBMITTER: Seung-Woo Shin 

PROVIDER: E-GEOD-45847 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress