Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state [Gene Expression Data]

ABSTRACT: A unifying characteristic of aggressive cancers is a profound anabolic shift in metabolism to enable sustained proliferation and biomass expansion. The ribosome is centrally situated to sense metabolic states but whether it impacts systems that promote cellular survival is unknown. Here, through integrated chemical-genetic analyses, we find that a dominant transcriptional effect of blocking protein translation in cancer cells is complete inactivation of heat shock factor 1 (HSF1), a multifaceted transcriptional regulator of the heat-shock response and many other cellular processes essential for tumorigenesis. Translational flux through the ribosome reshapes the transcriptional landscape and links the fundamental anabolic processes of protein production and energy metabolism with HSF1 a

ORGANISM(S): Homo sapiens

SUBMITTER: Marc Mendillo 

PROVIDER: E-GEOD-45851 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress