Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

ABSTRACT: Rev-Erba and Rev-Erbb are nuclear receptors that regulate the expression of genes involved in the control of circadian rhythm, metabolism, and inflammatory responses. Rev-Erbs function as transcriptional repressors by recruiting NCoR/HDAC3 co-repressor complexes to Rev-Erb response elements in enhancers and promoters of target genes, but the molecular basis for cell-specific programs of repression is not known. Here, we present evidence that in macrophages, Rev-Erbs regulate target gene expression by inhibiting the functions of distal enhancers that are selected by macrophage lineage-determining factors, thereby establishing a macrophage-specific program of repression. Remarkably, the repressive functions of Rev-Erbs are associated with their ability to inhibit the transcription of enhan

ORGANISM(S): Mus musculus

SUBMITTER: Michael Lam 

PROVIDER: E-GEOD-45914 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress