Resveratrol prevents diet-induced arterial degeneration and stiffening in nonhuman primates

ABSTRACT: Cardiovascular (CV) disease is a leading cause of morbidity and mortality in Western societies. Even after accounting for traditional CV risk factors (e.g. obesity, smoking and hypertension), the inflammation-driven thickening and stiffening of central arteries is a strong predictor of adverse outcomes. Arterial wall changes are universally associated with advancing age and show unparalleled worsening in metabolic syndrome. In mice, resveratrol ameliorates a high-fat diet induced arterial wall inflammation and slows age-associated physiologic deteriorations within the arterial wall. Here we tested resveratrol in adult male rhesus monkeys, an experimental model relevant to humans. A diet rich in fat and sucrose (HFS) led to an increase in body weight as well as thickening and stiffening of

ORGANISM(S): Macaca mulatta

SUBMITTER: Kevin Becker 

PROVIDER: E-GEOD-45927 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress