Linalool, an aromatic terpenoid, rewires transcriptome profile of lipid-loaded HepG2 cells

ABSTRACT: The microarray results showed that linalool sitimulation of lipid-loaded HepG2 cells rewired the hepatic transcriptome profile, with linalool being comparable to those of fenofibrate. Total of 8,988 genes that were commonly and significantly expressed in all experimental groups, including control hepatocytes, lipid-loaded hepatocytes, and lipid-loaded hepatocyted stimulated with linalool or fenofibrate, respectively, to compare the transcriptome profile of linalool (1mM) with those of hypotriglyceridemic drug, fenofibrate (100 ?M). Lipid loading of hepatocytes notably changed hepatic transcriptome profile, where 77 % of the selected genes showed >20% changes in expression (fold change > 1.2 or fold change <0.8). However, linalool stimulation of lipid-loaded cells showed that 48 % of the se

ORGANISM(S): Homo sapiens

SUBMITTER: Sung-Joon Lee 

PROVIDER: E-GEOD-45961 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress