Bach2 represses effector programmes to stabilize Treg-mediated immune homeostasis

ABSTRACT: Through their functional diversification, CD4+ T cells play key roles in both driving and constraining immune-mediated pathology. Transcription factors are critical in the generation and maintenance of cellular diversity and negative regulators antagonistic to alternate fates often act in conjunction with positive regulators to stabilize lineage specification1. Polymorphisms within the locus encoding a transcription factor BACH2 are associated with diverse immune-mediated diseases including asthma2, multiple sclerosis3, Crohn¹s disease4-5, coeliac disease6, vitiligo7 and type 1 diabetes8. A role for Bach2 in maintaining immune homeostasis, however, has not been established. Here, we define Bach2 as a broad regulator of immune activation that stabilizes immunoregulatory capacity while repre

ORGANISM(S): Mus musculus

SUBMITTER: Golnaz Vahedi 

PROVIDER: E-GEOD-45975 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress