MicroRNA-gene expression network in murine liver during Schistosoma japonicum infection

ABSTRACT: Schistosomiasis japonica remains a significant public health problem in China and Southeast Asian countries. The most typical and serious outcome of the chronic oriental schistosomiasis is the progressive granuloma and fibrosis in the host liver, which has been a major medical challenge. However, the molecular mechanisms that underlie the hepatic pathogenesis induced by schistosomal egg deposition have not yet been well-defined. Using microarrays, we quantified the temporal gene expression profiles in the liver of Schistosoma japonicum-infected BALB/c mice at day 15, 30, and 45 post infection (pi) with that from uninfected mice as controls. Meanwhile, microRNA expression profiles from the same samples were decoded by parallel solexa sequencing. Gene expression alternation associated with l

ORGANISM(S): Mus musculus

SUBMITTER: Pengfei Cai 

PROVIDER: E-GEOD-45985 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress