Transcriptome analysis of in vitro MSC-derived osteoblastic cells from patients with Primary Myelofibrosis

ABSTRACT: Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm whose severity and treatment complexity is attributed to the presence of bone marrow (BM) fibrosis and alterations of stroma impairing the production of normal blood cells. Despite the recently discovered mutations including the JAK2V617F mutation in about half of patients, the primitive event responsible for the clonal proliferation is still unknown. In the highly inflammatory context of PMF, the presence of fibrosis associated with a neo-osteogenesis and an osteosclerosis concomitant to the myeloproliferation and to the increase number of circulating hematopoietic progenitors suggests that the crosstalk between hematopoietic cells and the osteoblastic niche is deregulated in the PMF BM microenvironment. Osteoblastic nic

ORGANISM(S): Homo sapiens

SUBMITTER: christophe desterke 

PROVIDER: E-GEOD-46021 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress