Whole transcriptome profiling of the rat pineal gland during development from embryonic day 21 to adult

ABSTRACT: The transcriptome of the rat pineal gland is highly dynamic, with many hundreds of genes changing more than two-fold on a 24-hr daily rhythm, as revealed earlier using Affymetrix GeneChip analysis. Several key transcription factors and enzymes are known to change dramatically during development of the pineal gland. Studies on a small number of genes indicate that the onset of rhythmic expression generally occurs later in development. This study characterizes this temporally dynamic transcriptome using RNA-Seq to capture information regarding alternative splicing, novel exons, unannotated mRNAs, non-coding RNAs and coding transcripts not represented on the Affymetrix chips. The rat pineal transcriptome was sequenced in samples from four ages, from embryonic day 21 through adult. At each age

ORGANISM(S): Rattus norvegicus

SUBMITTER: Steven Coon 

PROVIDER: E-GEOD-46127 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress