Genome-wide analysis of E17.5 pituitary gland gene expression of control and Insm1 mutant mice

ABSTRACT: The Insm1 gene encodes a zinc finger factor expressed in many endocrine organs. We show here that Insm1 is required for differentiation of all endocrine cell types in the pituitary. Thus, in Insm1 mutant mice, hormones characteristic of the different pituitary cell types (thyroid, follicle and melanocyte stimulating hormone, adrenocorticotrope hormone, growth hormone and prolactin) are absent or produced at markedly reduced levels. The differentiation deficit is accompanied by an up-regulated expression of components of the Notch signaling pathway. Further, skeletal muscle-specific genes are ectopically expressed, indicating that Insm1 blocks a muscle-specific expression program. Since Insm1 is also essential for differentiation of endocrine cells in the pancreas, intestine and adrenal gla

ORGANISM(S): Mus musculus

SUBMITTER: Jochen Welcker 

PROVIDER: E-GEOD-46139 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress