Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures.

ABSTRACT: Acute respiratory illness (ARI) is the leading cause of asthma exacerbations yet the mechanisms underlying this association remain unclear. To address the deficiencies in our understanding of the molecular mechanisms driving ARI-induced asthma exacerbations, we undertook a transcriptional profiling study of the nasal mucosa over the course of ARI amongst individuals with a history of asthma, allergic rhinitis and no underlying respiratory disease. We found that ARI is characterized by dynamic, time-specific transcriptional profiles whose magnitudes of expression are influenced by underlying respiratory disease and the mucosal repair signature evoked during ARI. Most strikingly, we report that asthmatics that experience ARI-induced exacerbations are characterized by a reduced but prolonged

ORGANISM(S): Homo sapiens

SUBMITTER: Peter McErlean 

PROVIDER: E-GEOD-46171 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress