Perinatal bisphenol A exposure promotes dose-dependent alterations of the mouse methylome

ABSTRACT: Environmental factors during perinatal development influence developmental plasticity and disease susceptibility via alterations to the epigenome. Developmental exposure to the endocrine active compound, bisphenol A (BPA), has previously been associated with altered methylation at candidate gene loci. Here, we undertake the first genome-wide characterization of DNA methylation profiles in the liver of murine offspring perinatally exposed to multiple doses of BPA through the maternal diet. Using a tiered focusing approach, our strategy proceeds from unbiased broad DNA methylation analysis using methylation-based next generation sequencing technology to in-depth quantitative site-specific CpG methylation determination using the Sequenom EpiTYPER MassARRAY platform to profile liver DNA methy

ORGANISM(S): Mus musculus

SUBMITTER: Jung Kim 

PROVIDER: E-GEOD-46183 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress