Transcription profiling of mouse NFIA deficient mice brain

ABSTRACT: Background. Nuclear factor I-A (NFI-A), a phylogenetically conserved transcription/replication protein, plays a crucial role in mouse brain development. Previous studies showed that disruption of the Nfia gene in mice leads to perinatal lethality, corpus callosum agenesis, and hydrocephalus. Results. To identify potential NFI-A target genes involved in the observed tissue malformations, we analyzed gene expression in brains from NFI-A-deficient and wild-type littermate control mice at the mRNA level using oligonucleotide microarrays. In young postnatal animals (P16), 356 genes were detected as differentially regulated, whereas at the late embryonic stage (E18), only 5 dysregulated genes were found. An in silico analysis identified phylogenetically conserved NFI binding sites in at least 7

ORGANISM(S): Mus musculus

SUBMITTER: Yong Wee Wong 

PROVIDER: E-GEOD-4623 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress