Expression data of multiple sclerosis patients receiving Interferon-beta therapy [HG-U133_Plus_2]

ABSTRACT: The purpose of this study was to investigate the expression dynamics of mRNAs and microRNAs in response to subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) or relapsing-remitting type of the disease (RRMS). By using Affymetrix microarrays, we obtained gene expression profiles of peripheral blood mononuclear cells from 6 MS patients within the first month of IFN-beta treatment. EDTA blood samples were taken from all patients immediately before first, second and third IFN-beta injection as well as after 1 month. Total RNA of Ficoll-isolated peripheral blood mononuclear cells from each sample was extracted, labeled and hybridized to Affymetrix Human Genome U133 Plus 2.0 arrays to q

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Hecker 

PROVIDER: E-GEOD-46280 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress