Global Gene Expression Profiling in wildtype and PAI-1 Knockout Murine Heart and Kidney.

ABSTRACT: Fibrosis is defined as an abnormal matrix remodeling and loss of tissue homeostasis due to excessive synthesis and accumulation of extracellular matrix proteins in tissues. At present, there is no effective therapy for organ fibrosis. Previous studies demonstrated that aged plasminogen activator inhibitor-1(PAI-1) knockout mice develop spontaneously cardiac-selective fibrosis without affecting any other organs including kidney. Therefore, the PAI-1 knockout model of cardiac fibrosis provides an excellent opportunity to find the igniter(s) of cardiac fibrosis and its status in unaffected organs. We hypothesized that differential expressions of profibrotic and antifibrotic genes in PAI-1 knockout hearts and unaffected organs lead to cardiac selective fibrosis. In order to address this predic

ORGANISM(S): Mus musculus

SUBMITTER: Chunfa Jie 

PROVIDER: E-GEOD-46320 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress