Expression profiling of circulating miRNAs in Luminal A breast cancer

ABSTRACT: Breast cancer is a common disease with distinct tumor subtypes which can be phenotypically characterized by estrogen receptor, progesterone receptor and HER2/neu receptor status. MiRNAs play regulatory roles in tumor initiation and progression. Altered miRNA expression has been demonstrated in a variety of cancer states to date presenting the potential for exploitation as cancer specific biomarkers. Blood presents an attractive medium biomarker discovery. This study investigated systemic miRNAs differentially expressed in Luminal A (ER+PR+HER2/neu-) breast cancer and their effectiveness as oncologic biomarkers in the clinical setting. Blood samples were prospectively collected from consenting patients with Luminal A breast cancer (n=10) and controls (n=10). RNA was extracted, reverse trans

ORGANISM(S): Homo sapiens

SUBMITTER: Graham Ball 

PROVIDER: E-GEOD-46355 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress