Gene repression by sigmaS: sigma competition for binding to RNA polymerase or more?

ABSTRACT: The alternative subunit of RNA polymerase RpoS/M-OM-^CS controls a global adaptive response allowing many Gram-negative bacteria to survive nutrient deprivation and various stresses and contributes to biofilm formation and virulence of Salmonella enterica serovar Typhimurium. We have addressed an important but poorly understood aspect of M-OM-^CS-dependent control; that of a repressor. The general assumption is that negative regulation of gene expression by M-OM-^CS is mainly a passive phenomenon, due to competition between M-OM-^CS and other sigma factors for binding to a limited amount of core RNA polymerase (RNAP). Genome expression profiling and physiological characterization of mutants of Salmonella ser. Typhimurium deleted for rpoS or producing a M-OM-^CS protein efficient for bindin

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium

SUBMITTER: Monot Marc 

PROVIDER: E-GEOD-46380 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress