Regulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host

ABSTRACT: The gene expression of Trypanosoma brucei has been examined extensively in the blood of mammalian hosts and in forms found in the midgut of its arthropod vector, the tsetse fly. However, trypanosomes also undergo development within the mammalian bloodstream as they progress from morphologically M-bM-^@M-^Xslender formsM-bM-^@M-^Y to transmissible M-bM-^@M-^Xstumpy formsM-bM-^@M-^Y through morphological intermediates. This transition is temporally progressive within the first wave of parasitaemia such that gene expression can be monitored in relatively pure slender and stumpy populations as well as during the progression between these extremes. The development also represents the progression of cells from translationally active forms adapted for proliferation in the host to translationally

ORGANISM(S): Trypanosoma brucei brucei

SUBMITTER: Alasdair Ivens 

PROVIDER: E-GEOD-46388 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress