Lung conventional dendritic cells promote mucosal adjuvant activity of flagellin

ABSTRACT: The activity of the potent nasal adjuvant flagellin depends on initial activation of airway epithelilal cells. This study aims at investigating the immune cells involved in the antigen presentation within the respiratory tract. First, microarrays characterized that activation/recruitment of immune cells was the main signature of flagellin activation in lung. Neutrophils and classical monocytes were strongly recruited into the lungs and take up antigen upon nasal administration of flagellin. In contrast, the numbers of lung CD11b+ or CD103+ DC and alveolar macrophages were not enhanced although these cells were very efficient in antigen uptake. Our experiments showed that CD11b+ DC but not monocytes, PMN, CD103+ DC are not essential for the adjuvant effect. Flagellin signaling enhanced the

ORGANISM(S): Mus musculus

SUBMITTER: Hans-Joachim Mollenkopf 

PROVIDER: E-GEOD-46421 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress