Minotaur is critical for primary piRNA biogenesis [smallRNA-Seq]

ABSTRACT: Piwi proteins and their associated small RNAs are essential for fertility in animals. This is due, in part, to their roles in guarding germ cell genomes against the activity of mobile genetic elements. piRNA populations direct Piwi proteins to silence transposon targets and as such form a molecular code that discriminates transposons from endogenous genes. Information ultimately carried by piRNAs is encoded within genomic loci, termed piRNA clusters. These give rise to long, single-stranded, primary transcripts that are processed into piRNAs. Despite the biological importance of this pathway, neither the characteristics that define a locus as a source of piRNAs nor the mechanisms that catalyze primary piRNA biogenesis are well understood. We searched an EMS-mutant collection annotated

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Vasily Vagin 

PROVIDER: E-GEOD-46422 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress