Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage

ABSTRACT: Extracellular hemoglobin (Hb) has been recognized as a disease trigger in hemolytic conditions such as sickle cell disease, malaria and blood transfusion. In vivo, many of the adverse effects of free Hb can be attenuated by the Hb scavenger acute phase protein haptoglobin (Hp). The primary physiologic disturbances that can be caused be free Hb are found within the cardiovascular system and Hb triggered oxidative toxicity towards the endothelium has been promoted as a potential mechanism. The molecular mechanisms of this toxicity as well as of the protective activities of Hp are not yet clear. Within this study we systematically investigated the structural, biochemical and cell biologic nature of Hb toxicity in an endothelial cell system under peroxidative stress. We identified two principa

ORGANISM(S): Homo sapiens

SUBMITTER: Christian Schaer 

PROVIDER: E-GEOD-46471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress