Genome wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

ABSTRACT: The protozoan parasites Trypanosoma brucei spp. are responsible for important human and livestock diseases in sub Saharan Africa. In the mammalian blood, two developmental forms of the parasite exist: proliferative ?slender? forms and transmissible ?stumpy? forms that are quiescent, awaiting uptake in a tsetse fly bloodmeal. The slender to stumpy differentiation is a density-dependent response that resembles quorum sensing in microbial systems and is crucial for the parasite life cycle, ensuring both infection chronicity and disease transmission. The response is triggered by an elusive ?stumpy induction factor? (SIF) whose intracellular signaling pathway is also completely uncharacterized. Laboratory-adapted (monomorphic) trypanosome strains cannot respond to SIF, but can generate forms wi

ORGANISM(S): Trypanosoma brucei brucei

SUBMITTER: Alasdair Ivens 

PROVIDER: E-GEOD-46501 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress