Transcription profiling of mouse model of Helicobacter-induced gastric cancer

ABSTRACT: We have previously reported human gastrin overexpressing transgenic mice (=INS-GAS mice) and Helicobacter felis (=H.felis) infection synergistically accelerated gastric cancer in mice stomachs. (Wang et al 2000) Using this mouse model, we employed microarray analysis of gene expression profiling to identify gastric cancer-specific genes. Experiment Overall Design: 30 male INS-GAS mice (FVB/N background) were divided into groups: 15 mice were infected with H.felis at the age of 2-3 months and another 15 mice were not infected. 30 male non-transgenic FVB/N mice were also divided into 2 groups: 15 mice were infected with H.felis at the age of 2-3 months and another 15 mice were not infected. All mice were sacrificed after 6 months of H.felis infection, and total RNAs were extracted from who

ORGANISM(S): Mus musculus

SUBMITTER: Shigeo Takaishi 

PROVIDER: E-GEOD-4651 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress