Toxicogenomic analysis of ionic silver and silver nanoparticles on the fathead minnow and implications to human health

ABSTRACT: Nanoparticles are compounds of emerging concern with largely unknown risks for human and ecological health. It is crucial to evaluate their potential biological impact to prevent unintended adverse effects on human health and the environment. We analyzed the transcriptional effects of polyvinylpyrrolidone-coated silver nanoparticles (PVP-AgNPs) and silver nitrate (AgNO3) on the fathead minnow (Pimephales promelas) to understand their potential toxicity and adverse outcomes. We also tested the feasibility of the fathead minnow as an alternative species to elucidate potential adverse effects on humans. Fathead minnow females were exposed to either 4 µg/L of AgNO3 or 70 µg/L of PVP-AgNPs for 96h. Microarray analyses were performed on liver and brain. Functional analysis identified potential

ORGANISM(S): Pimephales promelas

SUBMITTER: Natalia Vinas 

PROVIDER: E-GEOD-46520 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress