RNA-seq in neurons derived from iPSCs in controls and patients with schizophrenia and 22q11 del

ABSTRACT: Induced pluripotent stem cell (iPSC) technology presents a unique opportunity to model schizophrenia (SCZ) and other neuropsychiatric disorders in vitro by providing investigators with the means to grow patient-specific neurons. Three approaches are possible regarding disease modeling for a genetically heterogenous disorder, like SCZ. One is the draw subjects from the general patient population who have suspected but undefined disease-causing genetic variants. Another is to focus on a common phenotype, such as clinical presentation, response to medications or age of onset. The third is to use patients who have on a common genetic etiology. We have chosen the latter approach and are developing a library of iPSCs from patients with SCZ who harbor chromosome 22q11.2 microdeletions. In this pr

ORGANISM(S): Homo sapiens

SUBMITTER: Herb Lachman 

PROVIDER: E-GEOD-46562 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress