Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia

ABSTRACT: Despite the advances in our understanding of aging-associated behavioral decline, we know relatively little about how aging affect neural circuits that underlie specific behaviors. Specifically, we know little about how aging affect expression of genes in specific neural circuits. We have now addressed this problem by exploring a cholinergic neuron R15, an identified neuron of marine snail Aplysia. R15 is characterized by bursting action potentials and is implicated in reproduction, osmoregulation and locomotion. We examined changes in gene expression in R15 neurons during aging by microarray analyses of RNAs prepared from two different age groups, mature and old animals. Specifically we find that 1083 ESTs are differentially regulated in mature and old R15 neurons. Bioinformatics analyse

ORGANISM(S): Aplysia californica

SUBMITTER: Sathyanarayanan Puthanveettil 

PROVIDER: E-GEOD-46618 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress