Inhibition of astroglial NF-kB regulates oligogenesis following spinal cord injury.

ABSTRACT: Astrocytes are taking the center stage in neurotrauma and neurological disease as they appear to play a dominant role in the inflammatory processes associated with these conditions. Previously, we reported that inhibiting nuclear factor kappa B (NF-kB) activation in astrocytes, by using a transgenic mouse model (GFAP-IκBα-dn mice), results in improved functional recovery following spinal cord injury (SCI), with increased white matter preservation and axonal sparing. In the present study we sought to determine whether this improvement, due to inhibiting NF-k-B activation in astrocytes, could be the result of enhanced oligogenesis in our GFAP-IκBα-dn mice. To gain insight into the underlying molecular mechanisms, we performed microarray analysis in naïve and 3 days, 3 and 6 weeks following S

ORGANISM(S): Mus musculus

SUBMITTER: John Bethea 

PROVIDER: E-GEOD-46695 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress