Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Smoking and Obesity Related Molecular Alterations in Clear Cell Renal Cell Carcinoma

ABSTRACT: Both cigarette smoking and obesity have been implicated in increased risk of clear cell renal cell carcinoma (ccRCC); however, there are limited data regarding the molecular mechanisms that underlie these associations. We used a multi-stage design to identify and validate specific molecular targets that are associated with smoking or obesity-related ccRCC. The data deposited herein are comprised of two batches of samples that were processed at two different time periods (please see Supplementary Data in Eckel-Passow et al. Carcinogenesis first published online December 28, 2013; doi:10.1093/carcin/bgt485). The first batch of samples consisted of 12 obese subjects and 13 non-obese subjects; all of whom were self-reported never-smokers. Each of the 12 obese subjects had microarray data available on both the patient-matched tumor and adjacent-normal tissues. All of the 13 non-obese subjects had microarray data available on the tumor tissue; however, only 9 of these 13 also had microarray data available on the patient-matched adjacent-normal tissue. The second batch of samples consisted of 16 self-reported smokers and 19 self-reported never smokers; all of whom were non-obese. This second batch of samples also contained 7 subjects who were obese and self-reported smokers. All subjects in the second batch had microarray data available on both the patient-matched tumor and adjacent-normal tissues. Lastly, two of the 13 patients in batch 1 were replicated in batch 2; both were non-obese and a non-smoker. These two technical replicates (two tumor samples and two normal samples) were included during normalization but removed prior to analysis. The cel files are Par007U133Plus2.0.CEL Par008U133Plus2.0.CEL Par041U133Plus2.0.CEL Par042U133Plus2.0.CEL The metadata "duplicate" column can also be used to exclude these samples. This dataset is part of the TransQST collection.

ORGANISM(S): Homo sapiens

SUBMITTER: Daniel Serie

PROVIDER: E-GEOD-46699 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Somatic expression of ENRAGE is associated with obesity status among patients with clear cell renal cell carcinoma.

Eckel-Passow Jeanette E JE Serie Daniel J DJ Bot Brian M BM Joseph Richard W RW Hart Steven N SN Cheville John C JC Parker Alexander S AS

Carcinogenesis 20131228 4

An association between obesity and development of clear cell renal cell carcinoma (ccRCC) has been established in the literature; however, there are limited data regarding the molecular mechanisms that underlie this association. Therefore, we used a multistage design to identify and validate genes that are associated with obesity-related ccRCC. We conducted a microarray study and compared gene expression between obese and non-obese subjects in ccRCC tumors and patient-matched normal kidney tissu ...[more]

PMID: 24374825

Publication: 1/2

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Dataset Information

Smoking and Obesity Related Molecular Alterations in Clear Cell Renal Cell Carcinoma

Publications

Somatic expression of ENRAGE is associated with obesity status among patients with clear cell renal cell carcinoma.

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