Enhanced upregulation of CRH mRNA expression in the rat nucleus accumbens after a delayed second injection of methamphetamine

ABSTRACT: Methamphetamine (METH) is a widely abused illicit amphetamine that causes acute biochemical and molecular changes in the brain. However, there are very few studies that have investigated the long-term effects of a single METH exposure in adult animals. The purpose of this study was thus to determine the consequences of a single injection of METH (10) mg/kg) on the biochemical and transcriptional effects of a second challenge injection of the drug (2.5 mg/kg) given one month later. Towards that end, we measured monoamine levels and gene expression by microarray and quantitative PCR analyses in the nucleus accumbens (NAc) of 4 groups of rats: saline-pretreated and saline-challenged (SS); saline-pretreated and METH-challenged (SM); METH-pretreated and saline-challenged (MS); and METH-pretrea

ORGANISM(S): Rattus norvegicus

SUBMITTER: Christie Brannock 

PROVIDER: E-GEOD-46717 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress