Prdm5 suppresses ApcMin-driven intestinal adenomas and regulates monoacylglycerol lipase expression

ABSTRACT: PRDM proteins are tissue specific transcription factors often deregulated in diseases, particularly in cancer where different members have been found to act as oncogenes or tumor suppressors. PRDM5 is a poorly characterized member of the PRDM family for which several studies have reported a high frequency of promoter hypermethylation in cancers of gastrointestinal origin. We report here the characterization of Prdm5 knockout mice in the context of intestinal carcinogenesis. We demonstrate that loss of Prdm5 increases the number of adenomas throughout the murine small intestine on an ApcMin background. By genome-wide ChIP-seq and transcriptome analyses we identify loci encoding proteins involved in metabolic processes as prominent PRDM5 targets and characterize monoacylglycerol lipase (Mgl

ORGANISM(S): Mus musculus

SUBMITTER: Raffaele Calogero 

PROVIDER: E-GEOD-46821 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress