De novo mutations in the genome organizer CTCF cause Intellectual Disability (RNA-Seq)

ABSTRACT: An increasing number of genes involved in chromatin structure and epigenetic regulation has been implicated in a variety of developmental disorders, often including intellectual disability. By trio exome sequencing and subsequent mutational screening we now identified two de novo frameshift mutations and one de novo missense mutation in the CTCF gene in individuals with intellectual disability, microcephaly and growth retardation. Furthermore, a patient with a larger deletion including CTCF was identified. CTCF (CCCTC-binding factor) is one of the most important chromatin organizers in vertebrates and is involved in various chromatin regulation processes such as higher order of chromatin organization, enhancer function, and maintenance of three-dimensional chromatin structure. Transcriptom

ORGANISM(S): Homo sapiens

SUBMITTER: Jo Huiqing Zhou 

PROVIDER: E-GEOD-46831 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress