Inheritance of gene expression level and selective constraints on trans- and cis-regulatory changes in yeast

ABSTRACT: Gene expression evolution can be caused by changes in cis- or trans-regulatory elements or both. As cis and trans regulation operate through different molecular mechanisms, cis and trans mutations may show different inheritance patterns and may be subjected to different selective constraints. To investigate these issues, we obtained and analyzed gene expression data from two Saccharomyces cerevisiae strains and their hybrid, using high-throughput sequencing. Our data indicate that compared to other types of genes, those with antagonistic cis-trans interactions are more likely to exhibit over- or under-dominant inheritance of expression level. Moreover, in accordance with previous studies, genes with trans variants tend to have a dominant inheritance pattern while cis variants are enriched

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Li-Ching Hsieh 

PROVIDER: E-GEOD-46838 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress