27-Hydroxycholesterol links cholesterol and breast cancer pathophysiology.

ABSTRACT: The cholesterol metabolite and SERM, 27HC, is the signaling molecule that links cholesterol to breast cancer pathophysiology Hypercholesterolemia is a risk factor for breast cancer, and patients taking statins demonstrate lower breast cancer incidence and decreased breast cancer recurrence, data that highlights the potential importance of the recent finding that 27-Hydroxycholesterol (27HC), a primary metabolite of cholesterol, acts as a selective estrogen receptor modulator (SERM). The goal of this study was to evaluate the impact of 27HC on breast cancer pathophysiology. Elevation of 27HC in murine models increased tumor growth in an estrogen receptor dependent manner. Importantly, a high cholesterol diet decreased the time to tumor onset and increased tumor growth, and this response req

ORGANISM(S): Homo sapiens

SUBMITTER: Jeff Jasper 

PROVIDER: E-GEOD-46924 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress