Aerobic training modulation of the host systemic milieu directly alters breast cancer cell phenotype in vitro.

ABSTRACT: Aberrant production and/or function of multiple host systemic factors (e.g., metabolic and immune-inflammatory mediators) act in concert to promote a ‘tumorigenic’ host milieu that directly promotes an aggressive malignant phenotype as well as drug resistance. Hence, strategies with the capacity to simultaneously act across multiple host systemic pathways may be required to optimize therapeutic outcomes in solid tumors. We hypothesized that chronic aerobic training, a pleiotropic whole-body intervention, modulates multiple systemic host pathways that, in turn, effectively alters cancer cell phenotype in vitro. Plasma samples from patients with solid tumors exposed to chronic aerobic training or sedentary control were comprehensively characterized for changes in immune, inflammatory, a

ORGANISM(S): Homo sapiens

SUBMITTER: Jeff Jasper 

PROVIDER: E-GEOD-46925 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress