A temperature-responsive network links cell shape and virulence traits in a primary fungal pathogen -- RNAi mutants (2)

ABSTRACT: The ability to grow at host temperature is a critical trait for most pathogenic microbes of humans. Thermally dimorphic fungal pathogens, including Histoplasma capsulatum, are a class of soil fungi that undergo a dramatic change in cell shape and virulence gene expression in response to host temperature. Here we elucidate a complex temperature-responsive network in H. capsulatum, which switches from an environmental filamentous form to a pathogenic yeast form. We dissect the circuit driven by three regulators that control yeast-phase growth, and demonstrate that these factors, including two deeply conserved Velvet family proteins of unknown function, associate with DNA. We identify and characterize a fourth regulator of this pathway, and define cis-acting motifs that recruit these transcri

ORGANISM(S): Ajellomyces capsulatus

SUBMITTER: Mark Voorhies 

PROVIDER: E-GEOD-46939 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress