Antivirulence activities of zinc ion and ZnO nanoparticle against Pseudomonas aeruginosa

ABSTRACT: An antivirulence approach targets bacterial virulence rather than cell viability in the antibiotic approach that can readily lead to drug resistance. Opportunistic human pathogen Pseudomonas aeruginosa produces a variety of virulence factors, and biofilm cells of this bacterium are much more resistant to antibiotics than planktonic cells. To identify novel inorganic antivirulence compounds, the dual screenings of thirty-six metal ions were performed to identify that zinc ions and ZnO nanoparticle inhibited the pyocyanin production and biofilm formation in P. aeruginosa without affecting the growth of planktonic cells. Moreover, zinc ion and ZnO nanoparticle markedly reduced the production of 2-heptyl-3-hydroxy-4(1H)-quinolone and siderophore pyochelin, while increased the production of ano

ORGANISM(S): Pseudomonas aeruginosa PAO1

SUBMITTER: Jintae Lee 

PROVIDER: E-GEOD-46947 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress