Transcriptome analysis of blood monocytes from sepsis patients

ABSTRACT: Blood monocytes serve as the first line of host defense and are equipped to recognize and respond to infection by triggering an immune-inflammatory response. While most information on these cells comes from in vitro studies in humans or in vivo studies in mice, little is known about monocytes under human disease conditions. We investigated the role of monocytes during sepsis and its resolution in humans. A transcriptomal and functional analysis of blood monocytes from patients during gram negative sepsis and at recovery was performed. Monocytes from sepsis patients showed upregulation of a large number of pro-inflammatory genes and cytokines/chemokines, consistent with an ongoing systemic inflammation. However, these cells showed impairment to ex vivo endotoxin (LPS) challenge, display

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Poidinger 

PROVIDER: E-GEOD-46955 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress