Transcription profiling of human ALL samples from very early relapsed childhood patients

ABSTRACT: Purpose: In childhood acute lymphoblastic leukemia (ALL), approximately 25% of patients suffer from relapse. In recurrent disease, despite intensified therapy, overall cure rates of 40% remain unsatisfactory and survival rates are particularly poor in certain subgroups. The probability of long-term survival after relapse is predicted from well-established prognostic factors, i. e. time and site of relapse, immunophenotype and minimal residual disease. However, the underlying biological determinants of these prognostic factors remain poorly understood. Results: We show here that patients with very early relapse of ALL are characterized by a distinctive gene expression pattern. We identified a set of 83 genes differentially expressed in very early relapsed ALL compared to late relapsed disea

ORGANISM(S): Homo sapiens

SUBMITTER: Renate Kirschner-Schwabe 

PROVIDER: E-GEOD-4698 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress