Gene expression changes induced by expression of MN1 deletion mutants in murine bone marrow cells

ABSTRACT: Extensive molecular profiling of leukemias and preleukemic diseases has revealed that distinct clinical entities, like acute myeloid (AML) and T-lymphoblastic leukemia, share the same pathogenetic mutations. It is not well understood how the cell of origin, accompanying mutations, extracellular signals or structural differences in a mutated gene determine the phenotypic identity of the malignant disease. We studied the relationship of different protein domains of the MN1 oncogene and their effect on the leukemic phenotype, building on the ability of MN1 to induce leukemia without accompanying mutations. We found that the most C-terminal domain of MN1 was required to block myeloid differentiation at an early stage, and deletion of an extended C-terminal domain resulted in loss of myeloid id

ORGANISM(S): Mus musculus

SUBMITTER: Adrian Schwarzer 

PROVIDER: E-GEOD-46990 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress