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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide map of p53 binding sites by ChIP-seq in human lymphoblastoid cell lines treated with ionizing radiation

ABSTRACT: We have used chromatin immune-precipitation with parallel sequencing (ChIP-Seq) technology to identify genome-wide p53 binding in human lymphoblastoid cell lines treated withionizing radiation ChIP-Seq analysis of p53 binding sites in human lymphoblastoid cells treated with ionizing radiation or vehicle

ORGANISM(S): Homo sapiens

SUBMITTER: Xuting Wang

PROVIDER: E-GEOD-46993 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection.

Zeron-Medina Jorge J Wang Xuting X Repapi Emmanouela E Campbell Michelle R MR Su Dan D Castro-Giner Francesc F Davies Benjamin B Peterse Elisabeth F P EF Sacilotto Natalia N Walker Graeme J GJ Terzian Tamara T Tomlinson Ian P IP Box Neil F NF Meinshausen Nicolai N De Val Sarah S Bell Douglas A DA Bond Gareth L GL

Cell 20131001 2

The ability of p53 to regulate transcription is crucial for tumor suppression and implies that inherited polymorphisms in functional p53-binding sites could influence cancer. Here, we identify a polymorphic p53 responsive element and demonstrate its influence on cancer risk using genome-wide data sets of cancer susceptibility loci, genetic variation, p53 occupancy, and p53-binding sites. We uncover a single-nucleotide polymorphism (SNP) in a functional p53-binding site and establish its influenc ...[more]

PMID: 24120139

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