MiR-203, a microRNA of multilayered epithelia, inhibits metastatic fitness in human squamous cell carcinoma

ABSTRACT: The colonization of distant organs by metastatic carcinoma cells underpins most human cancer-related deaths, including those from head and neck squamous cell carcinoma (HNSCC). We report that miR-203, a miRNA that promotes keratinocyte differentiation, is necessary and sufficient to inhibit multiple post-extravasation events during HNSCC lung metastasis, including initial survival/engraftment, escape from metastatic dormancy, and overt colonization in vivo. Restoration of miR-203 expression in established lung metastases reduces overall metastatic burden. Instead of promoting differentiation, miR-203 controls lung metastasis through direct targeting of genes involved in cytoskeletal dynamics (LASP1), ECM remodeling (SPARC), and cell metabolism (NUAK1). Expression of miR-203 and its downstr

ORGANISM(S): Homo sapiens

SUBMITTER: Nathan Benaich 

PROVIDER: E-GEOD-47028 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress