Transcription profiling of placenta from women who underwent a normal pregnancy and from those suffering from early or late onset pre-eclampsia

ABSTRACT: Pre-eclampsia is one of the most serious pregnancy-associated disorders, and is defined by hypertension (systolic blood pressure higher than 140mmHg or diastolic blood pressure higher than 90mmHg) with proteinuria (more than 0.3g/day). It is not a simple complication of pregnancy, but is rather a syndrome of multiple organ failure involving the liver, kidney, and lung, as well as coagulatory and neural systems. There is now an emerging consensus that pre-eclampsia is a complex polygenetic trait in which maternal and fetal genes, as well as environmental factors, are involved, although the precise mechanism of the disorder has remained elusive. In this study, we have performed gene expression profiling to further elucidate the mechanisms underlying the development of the pre-eclamptic condi

ORGANISM(S): Homo sapiens

DISEASE(S): early onset preeclampsia

SUBMITTER: Haruki Nishizawa 

PROVIDER: E-GEOD-4707 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress