Crosstalk between renal tumor suppressors: FLCN contributes to VHL tumor suppressing activity in renal cancer

ABSTRACT: Renal cancer accounts for 2% to 3% of all adult malignancies in the US. In 2011 more than 64,770 new cases and 13,000 deaths were reported and the incidence is steadily increasing by 2.5% per year. Clear cell renal carcinoma (ccRCC) represents the majority (85% to 90%) of adult kidney cancers and is the most malignant. This cancer is characterized by an early loss of the von Hippel-Lindau tumor suppressor (VHL) on short arm of chromosome 3 in the majority of tumors (80%). It is a classic knowledge that loss of VHL results in an increased accumulation and activity of the hypoxia-inducible transcription factor (HIF), which in turns activates expression of genes promoting tumor growth. In that respect, induction of angiogenic factors induces blood flow through the tumors and delivery of nutr

ORGANISM(S): Homo sapiens

SUBMITTER: Jing Chen 

PROVIDER: E-GEOD-47106 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress