Spaceflight Modulates Gene Expression in Astronauts

ABSTRACT: Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to infectious pathogens. Here we report the first microarray evaluation of any astronaut tissue sample, specifically whole blood, before and after spaceflight using an array comprising 234 well-characterized stress response genes. Differentially regulated genes included those important for DNA repair, oxidative stress, and protein folding/degradation. Microarrays comprising 234 well characterized stress-related genes were used to profile transcriptomic changes in six astronauts before and after short-duration spaceflight. Blood samples were collected for analysis from each eastronaut 10 days prior and 2-3 hours after

ORGANISM(S): Homo sapiens

SUBMITTER: Jennifer Barrila 

PROVIDER: E-GEOD-47126 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress