Epigenetic determinants of muscle stem cell quiescence and chronological aging

ABSTRACT: Skeletal muscle is a post-mitotic tissue that exhibits an extremely low turnover in the absence of disease or injury. At the same time, muscle possesses remarkable regenerative capacity mediated by satellite cells (SCs) that reside in close association with individual myofibers, underneath the fiber’s basal lamina. Consistent with the low turnover of the muscle, SCs in adult animals are mitotically quiescent and therefore provide an excellent model to study stem cell quiescence. As an organism grows older, the resident stem cells are exposed to a deteriorating environment and experience chronological aging. In stem cells with high turnover, the effects of chronological aging are superimposed upon the effects of the replicative aging that results from DNA replication and cell division. On t

ORGANISM(S): Mus musculus

SUBMITTER: Ling Liu 

PROVIDER: E-GEOD-47177 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress