Immunoglobulin-like domain receptor 1 mediates fat-stimulated cholecystokinin secretion.

ABSTRACT: Cholecystokinin (CCK) is a satiety hormone produced by discrete enteroendocrine cells scattered among absorptive cells of the small intestine. CCK is released into blood following a meal; however, the mechanisms inducing hormone secretion are largely unknown. Ingested fat is the major stimulant of CCK secretion. We recently identified a novel member of the lipoprotein remnant receptor family known as immunoglobulin-like domain containing receptor 1 (ILDR1) in intestinal CCK cells and postulated that this receptor conveyed the signal for fat-stimulated CCK secretion. In the intestine, ILDR1 is expressed exclusively in CCK cells. Orogastric administration of fatty acids elevated blood levels of CCK in wild type but not ILDR1-deficient mice, although the CCK secretory response to trypsin inhi

ORGANISM(S): Mus musculus

SUBMITTER: Rashmi Chandra 

PROVIDER: E-GEOD-47196 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress